las

Welcome all seeking refuge from low carb dogma!

“To kill an error is as good a service as, and sometimes even better than, the establishing of a new truth or fact”
~ Charles Darwin (it's evolutionary baybeee!)

Friday, April 13, 2018

Bio-HACK-ing Chronicles Ep.2: Maybe Jimmy Moore Has Hepatic Encephelopathy


No ... this blog will not become all Jimmy Moore, all the time.  I do have some posts in the works that just need some polish ... including one on the study Ted Naiman bases his 3:1 ratios of grams protein to fat that Jimmy was following.  That said, I can't help but put together a few comments on the Drama Llama supreme's latest n=1.


This Episode's n=1 bioHACK:   
  • 7 days of "Carnivore" , High Protein (mostly meat)
  • 3:1 grams protein:grams fat.   
  • 1.5 grams of protein per pound of lean body mass equaled 270 g protein:90 g fat.   (if you use 40% body fat, that puts his current weight at 300 ... )


RESULT:  Fail. 
If you listen at the 43 minute mark of this episode of The Keto Savage podcast, you'll see that it was Jimmy's every intention for this TO fail.

The purpose of biohacking is SUPPOSED to be about seeking out ways to improve one's overall health ... to achieve meaningful goals.  This nonsense of seeing what happens to his glucose and ketone readings here and there, ignore body weight entirely, get two insulin readings, estimate portions, etc. is all just nonsense.   He's not healing anything.  He's playing around with whatever healthy function he has left for social media likes and podcast downloads so he can sell keto stuff to earn affiliate dollars.  Sad really.

Tuesday, March 27, 2018

Bio-HACK-ing Chronicles Ep.1: What's with Jimmy Moore's HCT & Hb?


I've decided to chronicle some of the biohacking madness going on out there here on the blog.   I'm not sure if this helps anyone, but at least it will preserve some of it for posterity.   So this will randomly include publicly shared results of various "hacks" -- dietary or otherwise.

First up -- who else? LOL -- Jimmy Moore.  Fresh off his second 7-day fast in three weeks, Jimmy continues focusing on all the wrong things instead of actual improvements in things known to improve health.  Apparently low carb is/wasn't enough for Jimmy Moore, so he adopted an extreme version of a keto diet.  This worked swimmingly for a year until he stopped reporting his weight at the end of the year.  He rapidly regained the 80 re-lost pounds and embarked on his first extended fast in the fall of 2015.  That went so well he tried (unsuccessfully) to forego food for the entirety of January 2016, only to balloon up even further.  Forget the scale, I won't even post images, you've seen them all.  He is a profoundly unhealthy man despite cherry-picked biomarkers that appear to indicate otherwise.  

Jimmy Moore is obsessed with measuring ketones (everywhichway, apparently, but up the bum -- is an anal ketone test far behind?  LOL) and blood sugar.  Unless you are using insulin to control diabetes and/or concerned about ketoacidosis, or are on a therapeutic ketogenic diet for something like epilepsy, incessant glucose and (especially) ketone monitoring is pretty meaningless and probably neuroses-inducing in many.   

BOTTOM LINE:  When ANYONE (other than an IDDM) doesn't eat for a few days, their blood sugars will go down and their ketone levels will go up.  So big whoop that this happened to Jimmy Moore.  

I'm rather more interested in this:



Saturday, March 24, 2018

Keto will Change Your Life!


Just have to share, this ABSOLUTELY HILARIOUS clip from a recent episode of NCIS Los Angeles (Season 9, Episode 15, around 13 min in). 

Shared on Twitter and Facebook if you want to share on social media!

Monday, March 12, 2018

The Manhattan Project of Nutrition That Wasn't



With publication of the results of the second of the "Original 3" NuSI funded studies, I'm finally getting around to publishing up this post (and perhaps a second one shortly) regarding the Nutrition Science Initiative (NuSI), founded in 2012 by Peter Attia, MD and "science journalist" Gary Taubes. Bottom line ... for NuSI, it was "all over but the crying" a couple of years ago now. 







Monday, March 5, 2018

Dietary Energy Density and Incidence of Diabetes in the Women's Health Initiative


Summary:

In the Women's Health Initiative, a 2017 analysis of the energy density of baseline diets, stratified to quintiles, revealed several correlative components of an energy dense diet (comparing the top quintile (Q5) to the bottom (Q1).  The energy density, in kcal/gram of food, nearly doubled in Q5 vs. Q1 corresponding to a nearly 50% increase in caloric intake.  The dietary components correlating with this are:

  • Fat:  Fat content is by far and away the greatest contributing factor to consuming an energy dense diet.   Absolute intake more than doubled (2.5X) from Q1 to Q5, and comprised roughly 90% of the increased caloric intake.
  • Animal Protein:  As protein intake from plant sources remained relatively constant, animal protein intake increased by 40% resulting in an increase in total protein of 25%.  Therefore animal foods are a considerable contributor to increased energy density of the diet.
  • Added Sugars:  Added sugar comprised 11% of caloric intake across the quintiles, however absolute added sugar increased almost 50%.  
  • Carbohydrate:  Total carbohydrate intake is not associated with increased energy density of the diet.  Increases in added sugars were offset by reduction in other carbohydrates so that absolute intake remained constant.  Thus as a percentage of the caloric intake, carbohydrate declined significantly.
  • The macro percent composition of the least energy dense diets was P/F/C of 18/26/59, while the percents were 16/45/41 for the most energy dense diets.
The near doubling of energy density is associated with an (adjusted) roughly 25% increase in the risk of developing diabetes.



Monday, February 26, 2018

Maybe the Solution Lies in Making the Food Industry Our Friends


In our current times of rising obesity and chronic disease rates in the developed world (and spreading globally), I see a handful of "usual suspects" upon which the phenomenon is blamed:

  • The food industries
  • Governments and guidelines
  • The entertainment industries 
  • The general health and beauty industries
  • The diet and fitness industries 
By far and away, in no particular order, the two at the top of the list shoulder most of the blame.  You know the story by now.  Ancel Keys .... McGovern Committee ... Low fat dietary guidelines ... we got fat because CARBS and INSULIN!!!

Thursday, February 15, 2018

Keto Klarity Karma ~ All Aboard the Jimmy Moore Livin La Vida Low Carb Drama Express!!


You are forewarned:  


This post contains no science.  It's a bit of gossip and speculation, and simply exposing and documenting some goings on in the LLVLC and related worlds this past year and in recent times. There's no TL,DR.  But c'mon, I KNOW some of you are here at the Asylum for this stuff.  πŸ‘ΏπŸ˜ˆπŸ˜ˆπŸ˜‡πŸ˜‡

While it is possibly a royal waste of my time, I do think it is important to keep shining a light on the source of so much information on the internet.  Whether it's from Jimmy Moore directly, or through the filters of his podcasts, or the reality that he's an internationally best selling author of health and nutrition books, his level of disinformation cannot go unchecked. 

Lastly, much of this was written train of thought when it was going down.  I did my best to change tenses and edit out repetition in an effort to actually publish.  I make no promises. πŸ˜€


Friday, January 26, 2018

All Roads Lead Through Krebs ~ True Keto Clarity & The Truth About Fat Burning Beasts

Summary:


BUMPED January 26, 2018

This post was written around three and a half years ago, and through some bizarre twist of dietary fate, somehow ketogenic diets are still trending on Google for everything from weight loss to hang nails.  So I thought I'd bump this post which was my attempt at dispelling some myths regarding ketosis and the role of dietary protein in the mix.  

In the end, and some of these points are not made specifically in this post but I'll make them here:
  • Carbohydrate restriction is the greatest determinant of ketogenesis 
  • Protein (various amino acids) can feed into the Krebs Cycle and attenuate the reduction in oxaloacetate that favors ketogenesis from fatty acids.
  • Ketogenesis represents a conversion of fat energy to ketone energy but it is not evidence of the ultimate usage of that energy.  
  • Like glucose, ketones will be burned for energy before fatty acids, so ketogenesis is not an indicator of actual fatty acid oxidation ("fat burning")
  • Type 1 Diabetics have elevated ketogenesis and gluconeogenesis.  This is evidence that gluconeogenesis does not "kick one out of ketosis"!
  • The availability of gluconeogenic substrates is an unlikely cause for any elevation in blood glucose levels by stimulating gluconeogenesis.
  • Ketogenesis occurs in all of us at low levels, moreso when fasted and in caloric deficit.  But significant levels generally require significant metabolic dysregulation (e.g. Type 1 diabetes) or carbohydrate restriction.  The exception to this is high intake of MCTs.
  • Exogenous ketones are not "ketogenic" any more than eating a banana is "gluconeogenic".  Both simply directly supply the energetic substrate vs. creating it in the body.


Sunday, January 21, 2018

A quick note


I am unsure why, but I am experiencing some problems with notifications, reading and posting responses to comments.  This morning I posted one reply (I think, no notice it didn't go through) and then was unable to respond to another (kept getting some verification notice).  

In addition, I have been mostly on my phone as my computer screen cracked rendering it unusable until I managed to disable the touch screen.  With that successfully disabled, it's a crapshoot if the unit turns on for limited use.   I'm hoping Tuesday for my replacement.

I would *REALLY* love returning to more regular blogging in 2018.  

Saturday, January 13, 2018

Insulin Treatment in Diabetes ~ Why Does It Often Cause Weight Gain?


Summary:


Diabetes, whether Type 1 or Type 2, is a dysfunctional, wasteful metabolic state.  As a result, an uncontrolled diabetic either uses or loses more energy than their non-diabetic selves would otherwise use.  As such, the untreated diabetic is essentially "underweight" compared with the body weight that the same energy intake would produce were they not diabetic.

There are differences in endogenous insulin production between the two types of diabetes.  In Type 1, there is effectively no insulin production.  In Type 2, there is usually elevated basal insulin production, but a relative deficiency in acute insulin secretion, specifically an impaired early insulin response to glucose (GSIS). 

The absolute or relative insulin deficiency results in the following to a greater or lesser degree:
  1. Excessive lipolysis resulting in an increased cycling of the Triglyceride/Fatty Acid cycle.  
  2. Impaired suppression of glucose production in the liver, specifically an increase in glucose production via gluconeogenesis.
  3. Glycosuria (sometimes called glucosuria) due to impaired re-uptake of glucose in the kidneys and/or hyperglycemia exceeding re-uptake capacity.
All three of these are "Calories Out" in the Calories In - Calories Out (CICO) energy balance model.   Thus to greater or lesser degrees, diabetic individuals have greater energy expenditure.  When insulin therapy corrects these, energy expenditure is reduced.  Thus if the treated diabetic continues to consume their habitual amount of food, they will gain weight accordingly.   This is in contrast to the often postulated model whereby insulin treatment either induces hunger and overeating due to hypoglycemia, or the thoroughly debunked TWICHOO (aka the Carb-Insulin Hypothesis/Model) whereby insulin magically traps fat made from carbs in the fat cells thereby starving the rest of the body and causing hunger and overeating.  

The diabetic state also increases protein turnover rate, but this post focuses on the energetics.  While protein breakdown and synthesis require energy, the difference doesn't seem to be significant compared to total energy expenditure or the contributions of the three processes listed above.